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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 21, Recombinant, Mouse (IL-21)

Interleukin 21, Recombinant, Mouse (IL-21)

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Specifications

Interleukin-21 (IL-21) is a member of the common gamma-chain family of cytokines (includes IL-2, IL-4, IL-7, IL-9, IL-13, and IL-15) and is expressed by activated CD4+ T cells. IL-21 has a private receptor known as IL-21R, which is expressed on T, B, and NK cells. Within the B cell lineage, IL-21 regulates IgG1 production and cooperates with IL-4 for the production of multiple Ab classes in vivo. Initial studies have demonstrated that IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, natural killer, and dendritic cells.
Catalog #142925
SourceRecombinant protein corresponding to 130aa from mouse IL-21 expressed in E.coli.
Molecular Weight~15.1kD
Endotoxin 1EU/ug (LAL)
Biological ActivityThe activity is determined by a dose-dependent proliferation of lymphocytes co-stimulated with anti-CD3e and is typically 2-50ng/ml.
AA SequenceMHKSSPQGPD RLLIRLRHLI DIVEQLKIYE NDLDPELLSA PQDVKGHCEH AAFACFQKAK LKPSNPGNNK TFIIDLVAQL RRRLPARRGG KKQKHIAKCP SCDSYEKRTP KEFLERLKWL LQKMIHQHLS
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~15.1kD
SourceE.coli
Purity~95% (Reducing and non-reducing SDS-PAGE)
FormSupplied as a lyophilized powder in 20mM NaHCO3, pH 8.5. Reconstitute with sterile dH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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