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You are here:Home » Molecular Biology » Growth Factors-Interleukin » Interleukin 6, Recombinant, Human, Animal Free (IL-6, AF)

Interleukin 6, Recombinant, Human, Animal Free (IL-6, AF)

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Specifications

Interleukin 6 (IL-6) is an important pro-inflammatory and anti-inflammatory cytokine expressed by T cells, macrophages and muscle cells. IL-6 signals through a receptor complex containing two receptors, IL-6Ra and gp130. IL-6 has an important function in promoting fever and can serve to stimulate an immune response to trauma. IL-6 is often used for growth of hybridoma cell lines. Human IL-6 is active on mouse and rat cells.
Catalog #142945
SourceRecombinant protein corresponding to 184aa from human IL-6 expressed in E.coli.
Molecular Weight~21kD
Endotoxin 1EU/ug (LAL)
Biological ActivityThe activity is determined by the dose-dependant stimulation of mouse 7TD1 cells and is typcially <1ng/ml.
AA SequencePVPPGEDSKD VAAPHRQPLT SSERIDKQIR YILDGISALR KETCNKSNMC ESSKEALAEN NLNLPKMAEK DGCFQSGFNE ETCLVKIITG LLEFEVYLEY LQNRFESSEE QARAVQMSTK VLIQFLQKKA KNLDAITTPD PTTNASLLTK LQAQNQWLQD MTTHLILRSF KEFLQSSLRA LRQM
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~21kD
SourceE.coli
Purity~95% (Reducing and non-reducing SDS-PAGE)
FormSupplied as a lyophilized powder in 10mM acetic acid. Reconstitute with 10mM hydrochloride.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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