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You are here:Home » Molecular Biology » MB-Apoptosis » TRAIL, Recombinant, Human (TNF-Related Apoptosis-Inducing Ligand, Apo2L, TL2, Apo2 Ligand, TNFSF10, CD253)

TRAIL, Recombinant, Human (TNF-Related Apoptosis-Inducing Ligand, Apo2L, TL2, Apo2 Ligand,
TNFSF10, CD253)

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Specifications

TNF-Related Apoptosis-Inducing Ligand (TRAIL) is produced by a wide variety of cell types and is shown to be a cytotoxic protein that induces apoptosis in tumor cells through activation of the death receptors, DR4 and DR5. Human TRAIL is active on mouse cells.
Catalog #142991
SourceRecombinant protein corresponding to 168aa human TRAIL expressed in E.coli.
Molecular Weight~19.5kD
Endotoxin 1EU/ug (LAL)
Biological ActivityThe activity is determined by the ability to induce apoptotic cell death in TRAIL-sensitive RPMI-8226 cells and is typically 10-15ng/ml.
AA SequenceMRERGPQRVA AHITGTRGRS NTLSSPNSKN EKALGRKINS WESSRSGHSF LSNLHLRNGE LVIHEKGFYY IYSQTYFRFQ EEIKENTKND KQMVQYIYKY TSYPDPILLM KSARNSCWSK DAEYGLYSIY QGGIFELKEN DRIFVSVTNE HLIDMDHEAS FFGAFLVG
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~19.5kD
SourceE.coli
Purity~90% (HPLC, Reducing and non-reducing SDS-PAGE).
FormSupplied as a lyophilized powder in 10mM Na2PO4, pH 7.5, 50mM sodium chloride. Reconstitute with sterile dH2O.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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