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You are here:Home » Antibodies » Abs to Enzymes, Creatine Kinase » Anti -CKMT1 (Acidic-type mitochondrial creatine kinase, Mia-CK Ubiquitous mitochondrial creatine kinase, U-MtCK)

Anti -CKMT1 (Acidic-type mitochondrial creatine kinase, Mia-CK Ubiquitous mitochondrial
creatine kinase, U-MtCK)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins.
Catalog #143161
ApplicationsSuitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No13k34
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM NaCl, 0.2% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenPurified recombinant human CKMT1 protein fragments expressed in E. coli.
SpecificityRecognizes endogenous levels of CKMT1. Does not cross-react with related proteins. Species Crossreactivity: human, mouse
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names(Acidic-type mitochondrial creatine kinase, Mia-CK Ubiquitous mitochondrial creatine kinase, U-MtCK)


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