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You are here:Home » Growth Factors, Cytokines » Growth Factors-TGF » Activin A (E.coli-derived), Recombinant Human/Murine/Rat

Activin A (E.coli-derived), Recombinant Human/Murine/Rat

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Specifications

Activin A is a TGF-beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival.Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively.The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-beta antagonist, follistatin.Human/Murine/Rat Activin A is a 26.0kD disulfide-linked homodimer of two betaA chains, each containing 116 amino acid residues.
Catalog #143268
Biological ActivityThe ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ~2.0ng/ml, corresponding to a specific activity of ~5x10e5 units/mg.
AA SequenceGLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS
CrossreactivityChicken, Canine, Frog, Mouse, Human, Mouse
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity97% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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