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You are here:Home » Molecular Biology » Growth Factors-TNF » AITRL, Recombinant, Human (Activation-induced TNFR member Ligand, TNFSF18, GITRL, TL-6)

AITRL, Recombinant, Human (Activation-induced TNFR member Ligand, TNFSF18, GITRL, TL-6)

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Specifications

AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells.The AITRL gene codes for a type II transmembrane protein comprised of 177aa, including a 28aa cytoplasmic region, a 21aa transmembrane domain and a 128aa extracellular domain.Recombinant human soluble AITRL is a 14.4kD protein, containing 127aa residues corresponding to the extracellular domain of AITRL.
Catalog #143272
Biological ActivityDetermined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1-10ng/ml.
Note: Results may vary with PBMC donors.
AA SequenceMETAKEPCMAKFGPLPSKWQMASSEPPCVNKVSDWKLEILQNGLYLIYGQVAPNANYNDVAPFEVRLYKNKDMIQTLTNKSKIQNVGGTYELHVGDTIDLIFNSEHQVLKNNTYWGIILLANPQFI
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug)
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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