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You are here:Home » Molecular Biology » MB-Angiopoietin » ANGPTL3, Recombinant, Human (Angiopoietin-related Protein 3, Angiopoietin-5, ANG-5, Angiopoietin-like Protein 3, ANGPT5, UNQ153/PRO179)

ANGPTL3, Recombinant, Human (Angiopoietin-related Protein 3, Angiopoietin-5, ANG-5,
Angiopoietin-like Protein 3, ANGPT5, UNQ153/PRO179)

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Specifications

ANGPTL-3 (Angiopoietin like protein 3) is a member of the angiopoietinfamily of structurally related proteins, characterized by a coiled N-terminaldomain and a C-terminal fibrinogen like domain. It is primarily expressed inthe liver and can exert activities related to both angiogenesis and lipidmetabolism. ANGPTL-3 inhibits lipoprotein lipase (LPL) and endothelial lipase(EL), which has the effect of increasing plasma levels of triglycerides and HDLassociated cholesterol. The fibrinogen like portion of the ANGPTL-3 protein canbind alpha-5/beta-3 integrins leading to endothelial cell adhesion and migration. Recombinant human ANGPTL-3 isa glycoprotein that migrates by SDS-PAGE analysis at an apparent molecularweight of 62kD, and contains 452aa residues including a C-terminal His tag.
Catalog #143277
Biological ActivityMeasured by its binding ability to recombinant alpha v beta 3 integrin in a functional ELISA.
AA SequenceSRIDQDNSSF DSLSPEPKSR FAMLDDVKIL ANGLLQLGHG LKDFVHKTKG QINDIFQKLN IFDQSFYDLS LQTSEIKEEE KELRRTTYKL QVKNEEVKNM SLELNSKLES LLEEKILLQQ KVKYLEEQLT NLIQNQPETP EHPEVTSLKT FVEKQDNSIK DLLQTVEDQY KQLNQQHSQI KEIENQLRRT SIQEPTEISL SSKPRAPRTT PFLQLNEIRN VKHDGIPAEC TTIYNRGEHT SGMYAIRPSN SQVFHVYCDV ISGSPWTLIQ HRIDGSQNFN ETWENYKYGF GRLDGEFWLG LEKIYSIVKQ SNYVLRIELE DWKDNKHYIE YSFYLGNHET NYTLHLVAIT GNVPNAIPEN KDLVFSTWDH KAKGHFNCPE GYSGGWWWHD ECGENNLNGK YNKPRAKSKP ERRRGLSWKS QNGRLYSIKS TKMLIHPTDS ESFEHHHHHH HH
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceCHO cells
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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