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You are here:Home » Growth Factors, Cytokines » Growth Factors-BAFF » BAFF Receptor, Recombinant, Human (BAFFR, TNFRSF13C)

BAFF Receptor, Recombinant, Human (BAFFR, TNFRSF13C)

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Specifications

BAFF Receptor (BAFFR), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes.BAFFR is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B).BAFFR/BAFF signaling plays a critical role in B cell survival and maturation.Recombinant human BAFFR is a 76 amino acid polypeptide (7.7kD) corresponding to the extracellular portion of the full BAFFR protein.
Catalog #143287
Biological ActivityDetermined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0ug/ml in the presence of 1ug/ml of human soluble BAFF.
AA SequenceMRRGPRSLRGRDAPAPTPCVPAECFDLLVRHCVACGLLRTPRPKPAGASSPAPRTALQPQESVGAGAGEAALPLPG
CrossreactivityMouse
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity95% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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