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You are here:Home » Growth Factors, Cytokines » Growth Factors-EGF » Betacellulin, Recombinant, Mouse (BTC)

Betacellulin, Recombinant, Mouse (BTC)

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Specifications

Betacellulin is an EGF-related polypeptide growth factor that signals through the EGF receptor.It is produced in several tissues, including the pancreas, small intestine, and in certain tumor cells.Betacellulin is a potent mitogen for retinal pigment epithelial cells and vascular smooth muscle cells.Betacellulin is initially synthesized as a glycosylated 32.0kD transmembrane precursor protein, which is processed by proteolytic cleavage to produce the mature sequence.Recombinant murine Betacellulin is a 9.0kD monomeric protein, containing 80 amino residues, which comprises the mature EGF homologous portion of the Betacellulin protein.
Catalog #143290
Biological ActivityDetermined by its ability to stimulate the proliferation of mouse Balb/3T3 cells. The expected ED50 is ~0.01ng/ml, corresponding to a specific activity of ~1x10e8 units/mg.
AA SequenceDGNTTRTPET NGSLCGAPGE NCTGTTPRQK VKTHFSRCPK QYKHYCIHGR CRFVVDEQTP SCICEKGYFG ARCERVDLFY
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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