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You are here:Home » Growth Factors, Cytokines » Growth Factors-BMP » BMP-10, Recombinant, Human

BMP-10, Recombinant, Human

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Specifications

Bone morphogenetic proteins(BMPs) constitute a subfamily within the TGF-beta superfamily of structurallyrelated signaling proteins. Members of this superfamily are widely distributedthroughout the body and are involved in diverse physiological processes duringboth pre- and postnatal life.ampnbsp BMP-10 plays a crucial role in thedevelopment of the embryonic heart by acting to stimulate and maintain cardiomyocyteproliferation.ampnbsp It can signal through various receptor complexes usuallycontaining BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10with its specific receptors can induce signaling initiated by thephosphorylation of SMAD transcription factors, including SMAD1, SMAD5, orSMAD8, but can also induce SMAD independent processes.ampnbsp BMP-10 is structurallyrelated to BMP-9, and both can inhibit endothelial cell proliferation andmigration.ampnbsp Recombinant human BMP-10 is a24.4kD homodimeric disulfide-linked protein consisting of two 108 amino acidsubunits, which correspond to amino acid residues 317 to 424 of the full-lengthBMP-10 precursor.
Catalog #143291
Biological ActivityDetermined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 4-6ng/ml.
AA SequenceNAKGNYCKRT PLYIDFKEIG WDSWIIAPPG YEAYECRGVC NYPLAEHLTP TKHAIIQALV HLKNSQKASK ACCVPTKLEP ISILYLDKGV VTYKFKYEGM AVSECGCR
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceHEK293 cells
Purity95% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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