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You are here:Home » Growth Factors, Cytokines » Growth Factors-BMP » BMP-4, Recombinant, Mouse (BMP-2, BDVR4)

BMP-4, Recombinant, Mouse (BMP-2, BDVR4)

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Specifications

Bone morphogenetic proteins(BMPs) constitute a subfamily within the TGF-beta superfamily of structurallyrelated signaling proteins. Members of this superfamily are widely distributedthroughout the body and are involved in diverse physiological processes duringboth pre- and postnatal life. Like BMP-7, BMP-4 is involved in the developmentand maintenance of bone and cartilage. Reduced expression of BMP-4 isassociated with a number of bone diseases, including the heritable disorderFibrodysplasia Ossificans Progressiva. E.coli derived murine BMP-4 is a fully active homodimeric proteinconsisting of two 106 amino acid subunits which correspond to amino acids303-408 of the full length BMP-4 precursor.
Catalog #143295
Biological ActivityDetermined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-15ng/ml.
AA SequenceKKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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