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You are here:Home » Growth Factors, Cytokines » Growth Factors-BMP » BMP-5, Recombinant, Human

BMP-5, Recombinant, Human

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Specifications

TGF-beta family members arekey modulators of cell proliferation, differentiation, matrix synthesis, andapoptosis. As implied by their name, BMPs initiate, promote, and regulate thedevelopment, growth and remodeling of bone and cartilage. In addition to this role,BMPs are also involved in prenatal development and postnatal growth, remodelingand maintenance of a variety of other tissues and organs.nbsp BMP-5 isexpressed in the nervous system, lung and liver.nbsp It is a known regulatorfor dendritic growth in sympathetic neurons.nbsp BMP-5 is a 454 amino acidprecursor protein that is cleaved to release the biologically active C-terminalmature protein.nbsp Recombinant human BMP-5 is a 15.6kD homodimericdisulfide-linked protein consisting of two identical 138 amino acid chains.
Catalog #143296
Biological ActivityDetermined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1ug/ml.
AA SequenceAANKRKNQNR NKSSSHQDSS RMSSVGDYNT SEQKQACKKH ELYVSFRDLG WQDWIIAPEG YAAFYCDGEC SFPLNAHMNA TNHAIVQTLV HLMFPDHVPK PCCAPTKLNA ISVLYFDDSS NVILKKYRNM VVRSCGCH
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceCHO cells
Purity95% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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