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You are here:Home » Molecular Biology » Growth Factors-CTGF » CTGFL/WISP-2, Recombinant, Human (Connective Tissue Growth Factor-Like protein, CCN5, CT-58)

CTGFL/WISP-2, Recombinant, Human (Connective Tissue Growth Factor-Like protein, CCN5,
CT-58)

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Specifications

CTGFL/WISP-2 is a 28.6kD protein that belongs to the CCN family of cysteine rich regulatory proteins.Members of this family stimulate mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest, and migration of multiple cell types.The protein is expressed in primary osteoblasts, fibroblasts, ovary, testes, and heart.In addition to promoting adhesion of osteoblasts, CTGFL/WISP-2 inhibits osteocalcin production, as well as binding of fibrinogen to integrin receptors.Recombinant human CTGFL/WISP-2 is a 24.3kD protein of 228 amino acid residues.
Catalog #143304
Biological ActivityThe ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7 is between 10-20ng/ml in the presence of 15ng/ml of human IGF-II.
AA SequenceMQLCPTPCTCPWPPPRCPLGVPLVLDGCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYREGETFQPHCSIRCRCEDGGFTCVPLCSEDVRLPSWDCPHPRRVEVLGKCCPEWVCGQGGGLGTQPLPAQGPQFSGLVSSLPPGVPCPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPCPPSRGRSPQNSAF
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity95% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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