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You are here:Home » Molecular Biology » MB-Growth Factors-GDNF » GDNF, Recombinant, Mouse (Glial-Derived Neurotrophic Factor, ATF-1)

GDNF, Recombinant, Mouse (Glial-Derived Neurotrophic Factor, ATF-1)


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GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin.These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures.GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR alpha(alpha1-alpha4) receptors.GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons.Using Parkinsonrsquos disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability.The functional murine GDNF ligand is a disulfide-linked homodimer, of two 15.1kD polypeptide chains called monomers.Each monomer contains seven conserved cysteine residues, one of which is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
Catalog #143347
Biological ActivityThe ED50 was determined by the proliferation of rat C6 cells is ~0.2ng/ml, corresponding to a specific activity of ~5x10e6 units/mg.
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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