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You are here:Home » Growth Factors, Cytokines » Growth Factors-GM-CSF » GM-CSF, Recombinant, Rat (Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-alpha)

GM-CSF, Recombinant, Rat (Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2,
MGI-1GM, pluripoietin-alpha)

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Specifications

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells.It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes.GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells.The human and murine molecules are species-specific and exhibit no cross-species reactivity.Recombinant rat GM-CSF is a 14.5kD globular protein consisting of 128 amino acids residues.
Catalog #143350
Biological ActivityThe ED50 was determined by the dose-dependent stimulation of the proliferation of Murine FDC-P1 cells is ~0.01ng/ml, corresponding to a specific activity of ~1.0x10e8 units/mg.
AA SequenceMAPTRSPNPV TRPWKHVDAI KEALSLLNDM RALENEKNED VDIISNEFSI QRPTCVQTRL KLYKQGLRGN LTKLNGALTM IASHYQTNCP PTPETDCEIE VTTFEDFIKN LKGFLFDIPF DCWKPVQK
CrossreactivityMouse
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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