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You are here:Home » Growth Factors, Cytokines » Growth Factors-IGF » IGF-BP2, Recombinant, Human (IBP-2)

IGF-BP2, Recombinant, Human (IBP-2)

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Specifications

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids.Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II.IGF-BP2 is a cysteine-rich secreted protein produced by bone cells, and is most abundant in the brain.IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells.Recombinant human IGF-BP2 is a 31.5kD protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.
Catalog #143373
Biological ActivityDetermined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.
AA SequenceEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACQVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ
CrossreactivityMouse
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
Source(BTI-Tn-5B1-4) Hi-5 Insect cells*
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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