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You are here:Home » Molecular Biology » MB-Growth Factors-IGF » IGF-I, Recombinant, Mouse (Insulin-like Growth Factor-I, Somatamedin C, IGF-IA)

IGF-I, Recombinant, Mouse (Insulin-like Growth Factor-I, Somatamedin C, IGF-IA)


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The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro.IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times.The IGFs belong to the Insulin gene family, which also contains insulin and relaxin.The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin.IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone.Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor.Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions.Recombinant murine IGF-I is a 7.6kD globular protein containing amino acids including 3 intra-molecular disulfide bonds.
Catalog #143379
Biological ActivityThe ED50 was determined a cell proliferation assay using FDC-P1 cells is ~2.0ng/ml, corresponding to a specific activity of~5x10e5 units/mg.
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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