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You are here:Home » Molecular Biology » MB-Growth Factors-Interleukin » IL-13 (113 a.a.), Recombinant, Rat (NC300 (Human) P600 (Murine))

IL-13 (113 a.a.), Recombinant, Rat (NC300 (Human) P600 (Murine))


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IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells.Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1beta, TNF-alpha, IL-6 and IL-8.IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE.Blocking of IL-13 activity inhibits the pathophysiology of asthma.Human and murine IL-13 is cross-species reactive.Recombinant rat IL-13 is a 12.3kD protein consisting of 113 amino acid residues.
Catalog #143384
Biological ActivityThe ED50 was determined by the dose-dependent proliferation of TF-1 cells is 5.0ng/ml, corresponding to a specific activity of 2x10e5 units/mg.
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C.For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder. Reconstitute with sterile ddH2O to a concentration of 0.1-1.0mg/ml. Do not vortex. For long term add protein carrier. It is recommended that further dilutions be made into other aqueous buffers.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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