Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Molecular Biology » Growth Factors-Interleukin » IL-17 (IL-17A), Recombinant, Mouse (IL-17, CTLA-8)

IL-17 (IL-17A), Recombinant, Mouse (IL-17, CTLA-8)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.IL-17A exhibits cross-species bioactivity between human and murine cells.Recombinant murine IL-17A is a 30.0kD disulfide-linked homodimer of two 133 amino acid polypeptide chains.
Catalog #143387
Biological ActivityMeasured by its ability to induce IL-6 production by NIH 3T3 cells.
AA SequenceAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 6 months after receipt at -20°C. Reconstitute with sterile ddH2O, 0.1% BSA or HSA. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Certificate of OriginUSA
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses. Endotoxin:
0.1ng/ug of protein ( 1EU/ug).
FormSupplied as a lyophilized powder. Reconstitute in sterile ddH2O, 0.1% BSA or HSA to 0.1-1mg/ml. Do not vortex.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links