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You are here:Home » Molecular Biology » Growth Factors-Interleukin » IL-17 (IL-17A), Recombinant, Mouse (IL-17, CTLA-8)

IL-17 (IL-17A), Recombinant, Mouse (IL-17, CTLA-8)

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Specifications

The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules.Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles.The six known members of this family, IL-17A through IL-17F, are secreted as homodimers.IL-17A exhibits cross-species bioactivity between human and murine cells.Recombinant murine IL-17A is a 30.0kD disulfide-linked homodimer of two 133 amino acid polypeptide chains.
Catalog #143387
Biological ActivityMeasured by its ability to induce IL-6 production by NIH 3T3 cells.
AA SequenceAAIIPQSSA CPNTEAKDFL QNVKVNLKVF NSLGAKVSSR RPSDYLNRST SPWTLHRNED PDRYPSVIWE AQCRHQRCVN AEGKLDHHMN SVLIQQEILV LKREPESCPF TFRVEKMLVG VGCTCVASIV RQAA
CrossreactivityRat
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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