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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » IL-1Ra, Recombinant, Human (IL-1Ra, ICIL-1RA, IRAP, IL-1RN)

IL-1Ra, Recombinant, Human (IL-1Ra, ICIL-1RA, IRAP, IL-1RN)

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Specifications

Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring inflammatory inhibitor protein.It inhibits the activity of IL-1alpha and IL-1beta by competitively blocking binding to their type I and type II receptors.IL-1Ra is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts.Therapeutically, IL-1Ra may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.Recombinant human IL-1Ra is a 17.2kD protein consisting of 153 amino acid residues.
Catalog #143393
Biological ActivityDetermined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40ng/ml in the presence of 50 pg/ml of IL-1alpha;.
AA SequenceMRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
CrossreactivityFrog, Mouse, Rat
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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