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You are here:Home » Growth Factors, Cytokines » Growth Factors-Interleukin » IL-1 , Recombinant, Human (Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF))

IL-1 , Recombinant, Human (Catabolin, Lymphocyte-activating factor (LAF), Endogenous
Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF))

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Specifications

IL-1beta is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells.Both IL-1alpha and IL-1beta binds to the same receptor and has similar if not identical biological properties.These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells.However, whereas IL-1beta is a secreted cytokine, IL-1alpha is predominantly a cell-associated cytokine.Recombinant human IL-1beta is a 17.3kD protein containing 153 amino acid residues.
Catalog #143394
Biological ActivityThe ED50 as determined by the dose-dependent stimulation of thymidine uptake by murine D10S cells is ~1.0 pg/ml, corresponding to a specific activity of ~1x10e9 units/mg.
AA SequenceAPVRSLNCTL RDSQQKSLVM SGPYELKALH LQGQDMEQQV VFSMSFVQGE ESNDKIPVAL GLKEKNLYLS CVLKDDKPTL QLESVDPKNY PKKKMEKRFV FNKIEINNKL EFESAQFPNW YISTSQAENM PVFLGGTKGG QDITDFTMQF VSS
CrossreactivityFrog, Monkey, Mouse, Rabbit, Rat, Sheep
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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