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You are here:Home » Molecular Biology » Growth Factors-Interleukin » IL-3 , Recombinant, Rat (MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell stimulation factor)

IL-3 , Recombinant, Rat (MCGF (Mast cell growth factor), Multi-CSF, HCGF, P-cell
stimulation factor)

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Specifications

IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages.Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity.Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles.Many of the IL-3 activities depend upon co-stimulation with other cytokines.IL-3 is species-specific, variably glycosylated cytokine.Recombinant rat IL-3beta is a 16.3kD globular protein containing 144 amino acid residues.
Catalog #143408
Biological ActivityThe ED50 was determined by the dose-dependent stimulation of the proliferation of thymidine uptake by murine MC-9 cells is ~10ng/ml, corresponding to a specific activity of ~1.0x10e5 units/mg.
AA SequenceMISDRGSDAH HLLRTLDCRT IALEILVKLP YPQVSGLNNS DDKANLRNST LRRVNLDEFL KSQEEFDSQD TTDIKSKLQK LKCCIPAAAS DSVLPGVYNK DLDDFKKKLR FYVIHLKDLQ PVSVSRPPQP TSSSDNFRPM TVEC
CrossreactivityMouse
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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