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You are here:Home » Growth Factors, Cytokines » Growth Factors-GM-CSF » M-CSF, Recombinant, Rat (Macrophage Colony Stimulating Factor, CSF-1, MGI-IM)

M-CSF, Recombinant, Rat (Macrophage Colony Stimulating Factor, CSF-1, MGI-IM)

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Specifications

M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts.It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells.M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility.M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis.It facilitates hematopoietic recovery after bone marrow transplantation.The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells.Recombinant rat M-CSF is a 18.1kD homodimeric protein containing two 155 amino acid polypeptide subunits.
Catalog #143431
Biological ActivityThe ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ~5.0ng/ml, corresponding to a specific activity of ~2x10e5 units/mg.
AA SequenceMEVSEHCSHM IGNGHLQILQ QLIDSQMETA CLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNE ACVQTYKESP LRLLEKIKNF FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP
CrossreactivityMouse
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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