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You are here:Home » Growth Factors, Cytokines » Growth Factors-NGF » -NGF, Recombinant, Mouse

-NGF, Recombinant, Mouse

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Specifications

beta-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4.These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures.beta-NGF is a potent neurotrophic factor that signals through its receptor beta-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.beta-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival.The functional form of murine beta-NGF is a noncovalently disulfide-linked homodimer, of two 13.4kD polypeptide monomers (240 total amino acid residues).The three disulfide bonds are required for biological activity.
Catalog #143511
Biological ActivityThe ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ~1.0ng/ml, corresponding to a specific activity of ~1x10e6 units/mg.
AA SequenceSSTHPVFHMG EFSVCDSVSV WVGDKTTATD IKGKEVTVLA EVNINNSVFR QYFFETKCRA SNPVESGCRG IDSKHWNSYC TTTHTFVKAL TTDEKQAAWR FIRIDTACVC VLSRKATRRG
CrossreactivityHuman
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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