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You are here:Home » Molecular Biology » MB-Growth Factors-TGF » TGF- 3 (E. coli), Recombinant, Human (Transforming Growth Factor-beta3)

TGF- 3 (E. coli), Recombinant, Human (Transforming Growth Factor-beta3)


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The three mammalian isoforms of TGF-beta, TGF-beta1, beta2, beta3, signal through the same receptor and elicit similar biological responses.They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix.They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing.They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix.The release of biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1.The physiological role of TGF-beta3 is still unknown but its expression pattern suggests a role in the regulation of certain development processes.Recombinant human TGF-beta3 is a 25.0kD protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.
Catalog #143518
Biological ActivityThe ED50 was determined by TGF-beta3's ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ~0.05ng/ml, corresponding to a specific activity of ~2x10e7 units/mg.
CrossreactivityBovine, Canine, Mouse, Pig, Rat
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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