Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Molecular Biology » Growth Factors-Thrombopoietin » TPO, Recombinant, Human (Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL Ligand, MGDF)

TPO, Recombinant, Human (Thrombopoietin, Megakaryocyte colony-stimulating factor, c-MPL
Ligand, MGDF)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle.It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo.TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets.Human and murine TPO exhibits cross-species reactivity.Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6kD), which contains the erythropoietin-like domain of the full length TPO protein.
Catalog #143527
Biological ActivityThe ED50 as determined by the dose-dependent stimulation of the proliferation of human MO7e cells was found to be ~1.0ng/ml, corresponding to a specific activity of ~1x10e6 units/mg.
AA SequenceSPAPPACDLR VLSKLLRDSH VLHSRLSQCP EVHPLPTPVL LPAVDFSLGE WKTQMEETKA QDILGAVTLL LEGVMAARGQ LGPTCLSSLL GQLSGQVRLL LGALQSLLGT QLPPQGRTTA HKDPNAIFLS FQHLLRGKVR FLMLVGGSTL CVRRAPPTTA VPSRTSLVLT LNEL
CrossreactivityMonkey, Mouse
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceE. coli
Purity98% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links