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You are here:Home » Growth Factors, Cytokines » Growth Factors-VEGF » VEGF-C, Recombinant, Human (Vascular Endothelial Growth Factor-C, VRP, flt4 ligand)

VEGF-C, Recombinant, Human (Vascular Endothelial Growth Factor-C, VRP, flt4 ligand)

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Specifications

VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine.It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability.VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes.It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors.During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems.Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis.Recombinant human VEGF-C is a 13.5kD non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains.Due to glycosylation the protein migrates as a 20.0-22.0kD band under non-reducing condition.
Catalog #143539
Biological ActivityDetermined by its ability to support rat Retinal Ganglion Cells (RGC-5) cell growth in low serum media.
AA SequenceMAHYNTEILKSIDNEWRKTQCMPREVCIDVGKEFGVATNTFFKPPCVSVYRCGGCCNSEGLQCMNTSTSYLSKTLFEITVPLSQGPKPVTISFANHTSCRCMSKLDVYRQVHSIIRR
Quality ControlVerified by N-terminal and Mass Spectrometry analyses (when applicable).
Endotoxin<0.1ng/ug of protein (<1EU/ug).
Protein ContentVerified by UV Spectroscopy and/or SDS-PAGE gel.
Storage and StabilityStore lyophilized products at -20°C. For reconstituted solutions of most products, we recommend short-term storage at 4°C. For longer term storage the protein solution should be stored with a carrier protein (eg. 0.1% BSA) in working aliquots and stored frozen at -20°C. Additional freeze/thaw cycles may cause some denaturation of the protein.
SourceHEK293 cells
Purity95% by SDS-PAGE gel and HPLC analyses.
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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