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144166 Rabbit Anti-Annexin A4 (35-beta calcimedin, Annexin IV, Annexin-4, Carbohydrate-binding protein p33/p41, Chromobindin-4, Endonexin I, Lipocortin IV, P32.5, PP4-X, Placental anticoagulant protein II)

Specifications
References
Clone Type
Polyclonal
Host
Rabbit
Source
Human
Swiss Prot
P09525
Isotype
IgG
Grade
Affinity Purified
Applications
IHC WB
Crossreactivity
Hu Mo Rt
Gene ID
ANXA4
Shipping Temp
Blue Ice
Storage Temp
-20°C

Annexin IV, also known as placental anticoagulant protein II, or zymogen granule membrane-associated protein, 36-KD (ZAP36), is one of the family of calcium-dependent phospholipid-binding proteins whose normal function is uncertain. Annexin IV has 45 to 59% identity with other members of the annexin family. Annexin IV gene spans 18 to 56 kb. And it is located on mouse chromosome 6 in a region of conserved synteny with human chromosome 2. Rat annexin IV is ubiquitously expressed in epithelial tissues. Zap36 associated with zymogen granule membranes in dog and rat pancreas. Human annexin IV gene is mapped to chromosome 2p13.

UniProt Number
P09525
Gene ID
ANXA4
Applications
Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended Dilution
Immunohistochemistry: paraffin Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminal of human Annexin A4, different from the related mouse and rat sequences by one amino acid.
Form
Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitutie with 200ul sterile ddH2O.
Purity
Purified by immunoaffinity chromatography.
Specificity
Recognizes human, mouse and rat Annexin A4. No crossreactivity with other proteins.
References
1. Tait, J. F.; Smith, C.; Frankenberry, D. A.; Miao, C. H.; Adler, D. A.; Disteche, C. M. Chromosomal mapping of the human annexin IV (ANX4) gene. Genomics 12: 313-318, 1992. |2. Ponnampalam AP, Rogers PA.Cyclic changes and hormonal regulation of annexin IV mRNA and protein in human endometrium.Mol Hum Reprod. 2006 Nov;12(11):661-9. Epub 2006 Sep 5|3. Zschornig O, Opitz F, Muller M.Annexin A4 binding to anionic phospholipid vesicles modulated by pH and calcium.Eur Biophys J. 2007 Apr;36(4-5):415-24. Epub 2007 Mar 16.
USBio References
No references available
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