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You are here:Home » Antibodies » Abs to Collagen » Anti -Arresten (COL4A1, Collagen alpha-1 (IV) chain)

Anti -Arresten (COL4A1, Collagen alpha-1 (IV) chain)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Arresten , also known as COL4A1 (Collagen type IV, alpha-1). Type IV procollagen contains 2 distinct chains. The collagen IV molecule is a heterotrimer of 2 alpha-1 chains and 1 alpha-2 chain .The COL4A1 gene is mapped to chromosome 13 and it is expressed in human donor corneas. Human arresten binds to alpha-1/beta-1 integrin and inhibits migration, proliferation, and tube formation by endothelial cells. Arresten elicited significant antiangiogenic effects and tumor growth inhibition in vitro but failed to do the same in alpha-1 integrin knockout mice.
Catalog #144204
UniProt NumberP02462
Gene IDCOL4A1
ApplicationsSuitable for use in Western Blot.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and HandlingStore at -20 C for one year. After reconstitution, store at 4 C for one month. Can also be aliquoted and stored frozen at -20 C for long term.
Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to a sequence at the C-terminal of human Arresten, identical to the related rat and mouse sequence.
SpecificityRecognizes human, mouse and rat Arresten/COL4A1. No crossreactivity with other proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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