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You are here:Home » Antibodies » Abs to Protein Kinase Inhibitors » Anti -CDKN1C (Cyclin-dependent kinase inhibitor p57, p57Kip2)

Anti -CDKN1C (Cyclin-dependent kinase inhibitor p57, p57Kip2)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
CDKN1C(Cyclin-dependent kinase inhibitor 1C) also called p57(KIP2) or KIP2, is a protein which in humans is encoded by the CDKN1C imprinted gene. The CDKN1C gene encodes p57(KIP2), a potent tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. The CDKN1C gene is paternally imprinted, with preferential expression of the maternal allele. Matsuoka et al. (1995) demonstrated that the CDKN1C gene is located on chromosome 11p15.5, a region implicated in both sporadic cancers and Beckwith-Wiedemann syndrome, a familial cancer syndrome, making it a tumor suppressor candidate. The CDKN1C gene contains 3 exons. Mutations of CDKN1C are implicated in sporadic cancers and Beckwith-Wiedemann syndromesuggesting that it is a tumor suppressor candidate. Diaz-Meyer et al. (2005) concluded that CDKN1C may be downregulated by multiple mechanisms including some that do not involve promoter methylation.
Catalog #144359
UniProt NumberP49919
Gene IDCDKN1C
ApplicationsSuitable for use in Western Blot.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and HandlingStore at -20 C for one year. After reconstitution, store at 4 C for one month. Can also be aliquoted and stored frozen at -20 C for long term.
Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
Concentration~1mg/ml
FormSupplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to a sequence at the N-terminal of mouse , identical to the related rat sequence, and different from the related human sequence by two amino acids.
SpecificityRecognizes mouse and rat CDKN1C. No crossreactivity with other proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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