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You are here:Home » Antibodies » Abs to SOCS » Anti -CISH (CIS-1, Protein G18, Suppressor of cytokine signaling)

Anti -CISH (CIS-1, Protein G18, Suppressor of cytokine signaling)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH IC
CISH(cytokine inducible SH2-containing protein),also called CIS, CIS-1, G18, SOCS, is an important
negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling
(SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine
signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are
associated with susceptibility to bacteremia, tuberculosis and malaria. The human CISH gene is
mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on
chromosome 9, a region syntenic to human chromosome 3p21. CIS expression was upregulated by
lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved
downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression
of CIS. Gain- and loss-of-function studies showed that CIS accelerated degradation of IKBA and
enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.
Catalog #144368
UniProt NumberQ9NSE2
Gene IDCISH
ApplicationsSuitable for use in Western Blot, Immunohistochemistry (Paraffin) and Immunocytochemistry.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and HandlingStore at -20 C for one year. After reconstitution, store at 4 C for one month. Can also be aliquoted and stored frozen at -20 C for long term.
Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to a sequence at the C-terminal of human CISH, identical to the related rat and mouse sequences.
SpecificityRecognizes human, mouse and rat CISH. No crossreactivity with other proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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