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You are here:Home » Antibodies » Abs to Enzymes, Peroxiredoxin » Anti -PRDX1 (Natural killer cell-enhancing factor A)

Anti -PRDX1 (Natural killer cell-enhancing factor A)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
PRDX1(Peroxiredoxin 1), also called PRX1, PAGA or NKEFA, is a thiol reductase that plays critical
roles in oxidative and thermal stress defense mechanisms through its abilities to metabolize H2O2 and
act as a molecular chaperone, respectively. This gene encodes a member of the peroxiredoxin family of
antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The PRDX1 gene is
mapped on 1p34.1. Prdx1 was expressed in differentiating motor neuron cells in developing embryonic
chicken and mouse spinal cords. mmunoprecipitation analysis showed that GDE2 interacted directly
with PRDX1 in embryonic chicken spinal cord extracts and in transfected HEK293T cells. This protein
may have a proliferative effect and play a role in cancer development or progression. In differentiating
spinal cord, Prdx1 was required to activate Gde2 by reducing an intramolecular cystine bridge between
the Gde2 N- and C-terminal domains. An intramolecular disulfide bond between the GDE2 N- and
C-terminal domains inhibits GDE2 function, and that reduction of this cystine by PRDX1 activates GDE2
for the induction of motor neuron differentiation.
Catalog #145081
UniProt NumberQ06830
Gene IDPRDX1
ApplicationsSuitable for use in Western Blot.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and HandlingStore at -20 C for one year. After reconstitution, store at 4 C for one month. Can also be aliquoted and stored frozen at -20 C for long term.
Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to a sequence at the C-terminal of human PRDX1, different from the related rat and mouse sequences by one amino acid
SpecificityRecognizes human, mouse and rat PRDX1. No crossreactivity with other proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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