TRAF4

Clone Type

Polyclonal

Host

Rabbit

Source

Human

Swiss Prot

Q9BUZ4

Isotype

IgG

Grade

Affinity Purified

Applications

IHC WB

Crossreactivity

Hu Mo Rt

Gene ID

TRAF4

Shipping Temp

Blue Ice

Storage Temp

-20°C

TRAF4 (TNF Receptor-Associated Factor 4), also called CART1 or MLN62, is a protein that in humans is encoded by the TRAF3 gene. TRAF4 is a member of the TNF receptor associated factor (TRAF) family, a family of scaffold proteins. Tomasetto et al. (1995) identified genes that are overexpressed in breast cancer by differential screening of cDNAs from breast cancer-derived metastatic axillary lymph nodes. The TRAF4 cDNA, which they designated MLN62, was mapped to 17q11-q12 by radioisotopic in situ hybridization. To investigate the biologic function of TRAF4, Regnier et al. (2002) generated Traf4-deficient mice by gene disruption.

UniProt Number

Q9BUZ4

Gene ID

TRAF4

Applications

Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested.

Recommended Dilution

Immunohistochemistry: paraffin Optimal dilutions to be determined by the researcher.

Storage and Stability

Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Immunogen

A synthetic peptide corresponding to a sequence at the C-terminal of human TRAF4, identical to the related rat and mouse sequences.

Form

Supplied as a lyophilized powder from PBS, 5% BSA, 0.05% Thimerosal, 0.05% sodium azide. Reconstitutie with 200ul sterile ddH2O.

Purity

Purified by immunoaffinity chromatography.

Specificity

Recognizes human, mouse and rat TRAF4. No crossreactivity with other proteins.

References

1. Regnier, C. H., Masson, R., Kedinger, V., Textoris, J., Stoll, I., Chenard, M.-P., Dierich, A., Tomasetto, C., Rio, M.-C. Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. Proc. Nat. Acad. Sci. 99: 5585-5590, 2002. Note: Erratum: Proc. Nat. Acad. Sci. 99: 8457 only, 2002.|2. Regnier, C. H., Tomasetto, C., Moog-Lutz, C., Chenard, M.-P., Wendling, C., Basset, P., Rio, M.-C. Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. J. Biol. Chem. 270: 25715-25721, 1995.|3. Tomasetto, C., Regnier, C., Moog-Lutz, C., Mattei, M. G., Chenard, M. P., Lidereau, R., Basset, P., Rio, M. C. Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. Genomics 28: 367-376, 1995.|

USBio References

No references available

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145310 Rabbit Anti-TRAF4 (CART1, MLN62, RNF83, Cysteine-rich domain associated with RING and Traf domains protein 1, Metastatic lymph node gene 62 protein, , RING finger protein 83, Malignant 62, TNF receptor-associated factor 4)

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