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You are here:Home » Antibodies » Abs to Vitronectin » Anti -Vitronectin/VTN (S-protein, Serum-spreading factor, V75)

Anti -Vitronectin/VTN (S-protein, Serum-spreading factor, V75)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B
Vitronectin (VTN)also known as complement S-protein, serum spreading factor and somatomedin B is a
protein that in humans is encoded by the VTN gene. The protein encoded by this gene is a member of
the pexin family. Vitronectin is an abundant glycoprotein found in serum and the extracellular matrix and
promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic
complement pathway, and binds to several serpin serine protease inhibitors. Vitronectin is a 75 kDa
glycoprotein, consisting of 459 amino acid residues. By use of high resolution fluorescence in situ
hybridization (FISH), Fink et al. (1992) mapped the VTN gene to 17q11. The localization was confirmed
by cohybridization with a centromere-specific alphoid probe. About one-third of the protein's molecular
mass is composed of carbohydrates. It is a secreted protein and exists in either a single chain form or a
clipped, two chain form held together by a disulfide bond. Vitronectin has been speculated to be involved
in hemostasis and tumor malignancy.
Catalog #145359
UniProt NumberP04004
Gene IDVTN
ApplicationsSuitable for use in Western Blot.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and HandlingStore at -20 C for one year. After reconstitution, store at 4 C for one month. Can also be aliquoted and stored frozen at -20 C for long term.
Avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
PurityPurified by immunoaffinity chromatography.
ImmunogenA synthetic peptide corresponding to a sequence at the C-terminal of human Vitronectin, identical to the related rat and mouse sequences.
SpecificityRecognizes human, mouse and rat Vitronectin/VTN. No crossreactivity with other proteins.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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