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You are here:Home » Antibodies » Abs to Activin Receptors » Anti -ACVR1C (ALK-7, Activin Receptor-like Kinase 7, Activin RIC, ACVRLK7)

Anti -ACVR1C (ALK-7, Activin Receptor-like Kinase 7, Activin RIC, ACVRLK7)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E FC
Activin receptor-like kinase 7 (ALK-7), also known as Activin R1C (gene name ACVR1C), is a glycosylated 58kD type I receptor in the superfamily of TGF-beta serine/threonine kinase receptors. It associates with type II receptors to form a signaling complex that responds to the ligands Activin AB, and Activin B, GDF3, and Nodal. ALK-7 plays a role in regulating energy balance by inhibiting insulin secretion and inducing pancreatic beta cell apoptosis. It is expressed in adipose tissue but downregulated in obesity. ALK-7 is also expressed in pituitary gonadotropic cells and in pre-eclamptic placenta. It induces the apoptosis of trophoblasts as well as ovarian granulosa and epithelial cells. Within the extracellular domain, human ALK-7 shares 95% and 91% amino acid (aa) sequence identity with mouse and rat ALK-7, respectively. Alternate splicing of human ALK-7 generates additional isoforms with either a 50aa N-terminal truncation or with deletions of 79aa or 157aa that encompass the transmembrane segment.
Catalog #145379
ApplicationsSuitable for use in Flow Cytometry and ELISA. Other applications not tested.
Recommended DilutionFlow Cytometry: 2.5ug/10e6 cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No810506
HostMouse
SourceHuman
Concentration~0.5mg/ml (after reconstitution)
FormSupplied as a lyophilized powder in PBS, Trehalose. Reconstitute in sterile PBS.
PurityPurified by Protein A or G affinity chromatography.
ImmunogenRecombinant protein corresponding to aa26-113 from human ALK 7, CHO-derived (Accession# Q8NER5).
SpecificityRecognizes human ALK­7 in direct ELISAs.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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