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You are here:Home » Antibodies » Abs to Interleukin » Anti -IL-17 (Interleukin 17, CTLA-8, IL17A) (PE)

Anti -IL-17 (Interleukin 17, CTLA-8, IL17A) (PE)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified FC
The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation. IL-17 is induced by IL-15 and IL-23, mainly in activated CD4+ T cells distinct from Th1 or Th2 cells. IL-17F is the most homologous to IL-17, but is induced only by IL-23 in activated monocytes. IL-17B binds the IL-17B receptor, but not the IL-17 receptor; it is most homologous with IL-17D, which is expressed by resting CD4+ T cells and CD19+ B cells. IL-17E is mainly produced by Th2 cells and recruits eosinophils to lung tissue. IL-17C has a very restricted expression pattern but has been detected in adult prostate and fetal kidney libraries.
Catalog #145492
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: 0.5ml, 1x10e6 cells
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for 12 months at 4°C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity. PE conjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No41809
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in 0.5% BSA, 0.09% sodium azide. Labeled with R-Phycoerythrin (PE).
PurityPurified by Protein A affinity chromatography.
ImmunogenRecombinant protein corresponding to aa20-155 form human IL-17 expressed in E. coli (Accession# Q16552).
SpecificityRecognizes human IL-17.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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