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You are here:Home » Antibodies » Abs to Receptors, Scavenger » Anti -MARCO (SCARA2, Macrophage Receptor with Collagenous Structure, Scavenger Receptor Class A Member 2, SR-AII)

Anti -MARCO (SCARA2, Macrophage Receptor with Collagenous Structure, Scavenger Receptor
Class A Member 2, SR-AII)

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Specifications

Clone Host Grade Applications
Polyclonal Sheep Affinity Purified E B
MARCO (Macrophage receptor with collagenous structure; also scavenger receptor class A member 2/SR­AII) is a 65­70kD pattern recognition receptor/PRR that belongs to class A of the SR family, SRCR superfamily of molecules. It is expressed by macrophages, monocytes and Kupffer cells, and apparently binds to a number of microbes, including Gram+ bacteria (Staph and Strep) and Gram­ bacteria (Neisseria and coliforms), plus crystalline silica. Human MARCO is a 520 amino acid (aa) type II tranamembrane glycoprotein. It contains a 43aa cytoplasmic region and a 456aa extracellular domain/ECD (aa65­520). The ECD possesses one collagen­like region (aa147­419) and an SRCR domain (aa424­519). Human MARCO is believed to form trimers and/or multimers, and these are likely noncovalent associations. Over aa79­520, human and mouse MARCO share 70% aa sequence identity.
Catalog #145517
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 0.25ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O or PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostSheep
SourceHuman
Concentration~0.1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder in PBS, Trehalose. Reconstitute in sterile PBS.
PurityPurified by immunoaffinity chromatography.
ImmunogenRecombinant protein corresponding to aa79-520 from human MARCO, CHO-derived (Accession# Q9UEW3).
SpecificityRecognizes human MARCO in direct ELISAs and Western blots. Species Crossreactivity: ~10% recombinant mouse MARCO.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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