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145572 Mouse Anti-Plexin B2 (MM1, PLEXB2, PLXNB2)

Specifications
Clone Type
Monoclonal
Host
Mouse
Source
Human
Swiss Prot
O15031
Isotype
IgG2a
Clone Number
537219
Grade
Affinity Purified
Applications
E WB
Crossreactivity
Hu
Shipping Temp
Blue Ice
Storage Temp
-20°C

Plexin B2 is a 240kD member of the B subfamily, plexin family of semaphorin receptors. It is expressed by cerebellar granule cells, neuroepithelium and chondrocytes, and serves as a receptor for Semaphorin 4C. Mature human Plexin B2 is 1819 amino acid (aa) in length. It is a type I transmembrane (TM) glycoprotein that contains an 1178aa extracellular domain (ECD) plus a 620 aa cytoplasmic region. The ECD contains one semaphorin domain (aa20­466) and three IPT repeats (aa803­1092). The ECD may be cleaved into two subunits, a 170kD alpha­chain (aa20­1164) and an 80kD TM beta­chain that remain noncovalently­linked. Multiple splice variants may exist. One shows an alternate start site at Met1369, while a second shows a deletion of aa67­638. Over aa20­1160, human Plexin B2 is 82% aa identical to mouse Plexin B2.

Applications
Suitable for use in ELISA and Western Blot. Other applications not tested.
Recommended Dilution
Western Blot: 2ug/ml Optimal dilutions to be determined by the researcher.
Storage and Stability
Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Immunogen
Recombinant protein corresponding to aa20-1160 from human Plexin B2, CHO-derived (UniProt # O15031).
Form
Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 200ul sterile PBS.
Purity
Purified by Protein A or G affinity chromatography.
Specificity
Recognizes human Plexin B2 in direct ELISAs.
Conjugates
Pricing
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