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You are here:Home » Antibodies » Abs to Plexin, Semaphorin » Anti -Plexin B2 (MM1, PLEXB2, PLXNB2) (APC)

Anti -Plexin B2 (MM1, PLEXB2, PLXNB2) (APC)

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Specifications

Clone Host Grade Applications
Monoclonal Rat Affinity Purified FC
Plexin B2 is a 240kD type I transmembrane (TM) glycoprotein of the Plexin B family of semaphorin receptors. The mouse Plexin B2 cDNA encodes 1842 amino acids that include a 19 amino acid (aa) signal sequence, a 1182aa extracellular domain (ECD), a 21aa TM domain, and a 620 aa cytoplasmic region. Plexin B2 mRNA is expressed in proliferating cerebellar granule cell progenitors, neuroepithelium, developing neurons, growth plate chondrocytes, tooth bud inner enamel epithelium, glomeruli and mesenchyme of the developing kidney, and in germinal center B lymphocytes when T cell help is present. Plexin B2 is often coexpressed with Plexin B1, and the two may form heterodimers. Genetic deletion of mouse Plexin B2 results in defects in proliferation and migration of cerebellar granule cells, abnormal development of the neural tube and disorganization of the embryonic brain; these defects are not seen when Plexin B1 is deleted. In adults, Plexin B2 is expressed in specialized vascular endothelia, pancreatic islets of Langerhans, and adrenal glands. Plexin B2 serves as a receptor for type 4 semaphorins, especially Sema4C and Sema4G. B Plexins, including Plexin B2, can bind the scatter factor receptors, Met and Ron, and activate them upon semaphorin engagement.
Catalog #145573
ApplicationsSuitable for use in Flow Cytometry. Other applications not tested.
Recommended DilutionFlow Cytometry: 10ul, 1x10e6 cells
Optimal dilutions to be determined by the researcher.
HybridomaMouse myeloma cells with B cells from Balb/c rats.
Storage and StabilityMay be stored at 4°C before opening. DO NOT FREEZE! Stable at 4°C as an undiluted liquid. Dilute only prior to immediate use. Stable for at 12 months at 4°C. Freezing allophycocyanin conjugates will result in a substantial loss of activity. Allophycocyaninconjugates are sensitive to light.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No772417
HostRat
SourceMouse
ConcentrationAs reported
FormSupplied as a liquid in PBS, 0.5% BSA, 0.1% sodium azide. Labeled with Allophycocyanin (APC).
PurityPurified by Protein A or G affinity chromatography.
ImmunogenRecombinant protein corresponding to aa20-1029 from mouse Plexin B2, CHO-S-derived (Accessio # B2RXS4).
SpecificityRecognizes mouse Plexin B2.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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