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You are here:Home » Biochemicals » Biochem-Mycotoxins » Fumitremorgin C (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione)

Fumitremorgin C
(5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,1
4H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione)

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Specifications

Inhibitor of BCRP-mediated multidrug resistance. Chemosensitizing agent; selectively reverses BCRP-mediated multidrug resistance to mitoxantrone, doxorubicin and topotecan in transfected MCF-7 cells. Does not reverse resistance in P-gp- or MRP-positive cells.
Catalog #145674
SequenceC22H25N3O3
SolubilityDMSO (~10mM)
Molecular Weight~379.45
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
CAS Number118974-02-0
Molecular FormulaC22H25N3O3
Molecular Weight~379.45
Purity~98% (HPLC)
ConcentrationNot determined
FormSupplied as an off-white lyophilized solid.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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