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You are here:Home » Molecular Biology » Growth Factors-Activin, Inhibin » Activin A, Recombinant, Human/Mouse/Rat, aa311-426 (Activin A GMP, INHBA)

Activin A, Recombinant, Human/Mouse/Rat, aa311-426 (Activin A GMP, INHBA)

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Specifications

Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Activin proteins have a wide range of biological activities, including mesoderm induction, neural cell differentiation, bone remodeling, hematopoiesis and roles in reproductive physiology. Activin isoforms and other members of the TGF-beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction.
Catalog #145698
Activins are homodimers or heterodimers of the various beta subunit isoforms, while inhibins are heterodimers of a unique alpha subunit and one of the various beta subunits. Five beta subunits (mammalian beta A, beta B, beta C, beta E and Xenopus beta D) have been cloned to date. The activin/inhibin nomenclature reflects the subunit composition of the proteins Activin A (beta A -beta A), Activin B (beta B - beta B), Activin AB (beta A - beta B), Inhibin A (alpha-beta A) and Inhibin B (alpha-beta B).
SourceRecombinant protein corresponding to aa311-426 from human Activin A GMP, CHO-derived.
Molecular Weight~15kD
Endotoxin<0.10EU/1ug (LAL method)
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute in sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight~15kD
Purity~97% (SDS-PAGE)
Concentration~0.1mg/ml (after reconstitution)
FormSupplied as a lyophilized powder in Acetonitrile, TFA. BSA free. Reconstitute in 100ug/ml PBS.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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