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You are here:Home » Antibodies » Abs to Transmembrane Proteins » Anti -ANO1 (Anoctamin-1, Discovered on Gastrointestinal Stromal Tumors Protein 1, Oral Cancer Overexpressed Protein 2, Transmembrane Protein 16A, Tumor-amplified and Overexpressed Sequence 2, DOG1, ORAOV2, TAOS2, TMEM16A, FLJ10261)

Anti -ANO1 (Anoctamin-1, Discovered on Gastrointestinal Stromal Tumors Protein 1, Oral
Cancer Overexpressed Protein 2, Transmembrane Protein 16A, Tumor-amplified and
Overexpressed Sequence 2, DOG1, ORAOV2, TAOS2, TMEM16A, FLJ10261)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IF
Calcium-activated chloride channels (CaCC) are present in many cell types and mediate physiological functions such as epithelial secretion, sensory signal transduction, and smooth muscle contraction. Subunits of these CaCC's include the transmembrane proteins TMEM16A and TMEM16B. TMEM16A is expressed in epithelial cells of the kidney and lung, pancreas, and sensory neurons and its mRNA is seen in foregut, airway epithelia, and tracheal smooth muscle; mice lacking TMEM16A fail to survive past ten days and show aerophagia and little weight gain. TMEM16A is also overexpressed or amplified in multiple cancers associated with poor survival such as oral cancers and gastrointestinal stromal tumors, suggesting the development of CaCC modulators may be a viable therapeutic strategy.
Catalog #146525
ApplicationsSuitable for use in Immunofluorescence, ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Immunofluorescence: 20ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlA549 Cell Lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 17aa from near the N-terminus of human TMEM16A.
SpecificityRecognizes human TMEM16A. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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