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You are here:Home » Antibodies » Abs to Sirtuins » Anti -Sirtuin 1 (SIRT1, hSIRT1, NAD-dependent Protein Deacetylase Sirtuin-1, hSIR2, Regulatory Protein SIR2 Homolog 1, SIR2-like Protein 1, SIR2L1)

Anti -Sirtuin 1 (SIRT1, hSIRT1, NAD-dependent Protein Deacetylase Sirtuin-1, hSIR2,
Regulatory Protein SIR2 Homolog 1, SIR2-like Protein 1, SIR2L1)

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Chicken Affinity Purified E B IF
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and have important functions in the regulation of metabolism, growth and differentiation, inflammation, cellular survival, as well as in senescence and lifespan extension. Sirtuins, including SIRT1-7, are human homologs of yeast Sir2p. Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) which regulate cellular metabolism, e.g. energy metabolism, and thereby are associated with aging and several age-related diseases. SIRT1 has the closest homology to the yeast Sir2p and is widely expressed in fetal and adult tissues. SIRT1 regulates the p53-dependent DNA damage response pathway by binding to and deacetylating p53, specifically via lysine residue.
Catalog #146663
ApplicationsSuitable for use in Immunofluorescence, ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlMouse Liver Tissue Lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgY
HostChicken
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 19aa from near the N-terminus of human SIRT1.
SpecificityRecognizes human SIRT1. Species Crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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