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You are here:Home » Antibodies » Abs to Inflammasomes » Anti -NALP4 (NACHT-, LRR-and PYD-containing Protein 4, NACHT Leucine Rich Repeat and PYD Containing 4, CLR19.5, FLJ32126, Nucleotide Binding Oligomerization Domain Leucine Rich Repeat and Pyrin Domain Containing 4, NLR Family Pyrin Domain Containing 4, NLRP4, P

Anti -NALP4 (NACHT-, LRR-and PYD-containing Protein 4, NACHT Leucine Rich Repeat and PYD
Containing 4, CLR19.5, FLJ32126, Nucleotide Binding Oligomerization Domain Leucine Rich
Repeat and Pyrin Domain Containing 4, NLR Family Pyrin Domain Containing 4, NLRP4, P

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP4, also known as PYRIN-containing APAF1-like protein 4, has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. In transfected 293 cells, NALP4 suppressed NF-kB induction by TNF-a and IL-1b, suggesting NALP4 operates at a point of convergence in these two signaling pathways. NALP4 also suppressed NF-kB induction resulting from overexpression of several adapter proteins and protein kinases involved in these pathways, including TRAF2, TRAF6, RIP, and IRAK2, as well as the IKK-a and IKK-b, suggesting that NALP4 is critical in modulating NF-kB activity.
Catalog #146720
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlK562 Cell Lysate
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to 13aa from near the center of human NALP4.
SpecificityRecognizes human NALP4. Species Crossreactivity: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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