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You are here:Home » Molecular Biology » Growth Factors-Defensin » BD4, Recombinant, Human (Defensin, beta 104, HBD-4, BD-4, Beta-defensin 104, Beta-defensin 4, DEFB-4, DEFB104A, DEFB104, DEFB4, DEFB104B)

BD4, Recombinant, Human (Defensin, beta 104, HBD-4, BD-4, Beta-defensin 104, Beta-defensin
4, DEFB-4, DEFB104A, DEFB104, DEFB4, DEFB104B)

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Specifications

Defensins (alpha and beta) are cationic peptides with a broad spectrum of antimicrobial activity that comprise an important arm of the innate immune system. The alpha-defensins are distinguished from the beta-defensins by the pairing of their three disulfide bonds. To date, four human beta-defensins have been identified; BD-1, BD-2, BD-3 and BD-4. The beta-defensin proteins are expressed as the C-terminal portion of precursors and are released by proteolytic cleavage of a signal sequence. beta-defensins contain a six-cysteine motif that forms three intra-molecular disulfide bonds. beta-defensins are 3-5kD peptides ranging in size from aa33-47. BD-4 is expressed in testis, stomach, uterus, neutrophils, thyroid, lung and kidney. In addition to its direct antimicrobial activities, BD-4 is chemoattractant towards human blood monocytes. Recombinant human BD-4 is a 6kD protein containing 50aa.
Catalog #149563
SourceRecombinant protein corresponding to human BD-4, expressed in E. coli.
Biological ActivityDetermined by its ability to chemoattract human monocytes using a concentration range of 0.1-100ng/ml.
Endotoxin Level<0.1ng/ug (1EU/ug)
AA SequenceEFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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