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You are here:Home » Growth Factors, Cytokines » Growth Factors-IGF » IGFBP5, Recombinant, Human (Insulin-like Growth Factor-binding Protein 5, IBP-5, IGF-binding Protein 5, IGFBP-5, IBP5)

IGFBP5, Recombinant, Human (Insulin-like Growth Factor-binding Protein 5, IBP-5,
IGF-binding Protein 5, IGFBP-5, IBP5)

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Specifications

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP5 is a 28.6kD cysteine-rich secreted protein produced by vascular smooth muscle cells. It is the major IGF-binding protein present in bone tissue and helps potentiate the action of IGF-I on smooth muscle cells, fibroblasts or osteoblasts. Data shows that IGFBP-5 acts as a growth inhibitor and pro-apoptotic agent in breast cancer cells. IGFBP-5 overexpressing mice show an increase in neonatal mortality, reduced female fertility, whole-body growth inhibition and retarded muscle development. Recombinant human IGF-BP5 is a 28.6kD protein consisting of 253aa.
Catalog #149574
SourceRecombinant protein corresponding to human IGF-BP5, expressed in E. coli.
Biological ActivityDetermined by its ability to inhibit IGF-II induced proliferation of MCF-7. The ED50 was found to be 0.3ug/ml in the presence of 15ng/ml of human IGF-II.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMLGSFVHCEP CDEKALSMCP PSPLGCELVK EPGCGCCMTC ALAEGQSCGV YTERCAQGLR CLPRQDEEKP LHALLHGRGV CLNEKSYREQ VKIERDSREH EEPTTSEMAE ETYSPKIFRP KHTRISELKA EAVKKDRRKK LTQSKFVGGA ENTAHPRIIS APEMRQESEQ GPCRRHMEAS LQELKASPRM VPRAVYLPNC DRKGFYKRKQ CKPSRGRKRG ICWCVDKYGM KLPGMEYVDG DFQCHTFDSS NVS
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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