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You are here:Home » Growth Factors, Cytokines » Growth Factors-IGF » IGFBP3, Recombinant, Human (Insulin-like Growth Factor-binding Protein 3, IBP-3, IGF-binding Protein 3, IGFBP-3, IBP3)

IGFBP3, Recombinant, Human (Insulin-like Growth Factor-binding Protein 3, IBP-3,
IGF-binding Protein 3, IGFBP-3, IBP3)

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Specifications

IGF-BP3 is a 30kD cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in a-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8kD protein consisting of 264aa.
Catalog #149577
SourceRecombinant protein corresponding to human IGF-BP3, expressed in E. coli.
Biological ActivityDetermined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is 0.2ug/mlin presence of 15ng/ml of human IGF-II.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceGASSGGLGPV VRCEPCDARA LAQCAPPPAV CAELVREPGC GCCLTCALSE GQPCGIYTER CGSGLRCQPS PDEARPLQAL LDGRGLCVNA SAVSRLRAYL LPAPPAPGNA SESEEDRSAG EVESPSVSST HRVSDPKFHP LHSKIIIIKK GHAKDSQRYK VDYESQSTDT QNFSSESKRE TEYGPCRREM EDTLNHLKFL NVLSPRGVHI PNCDKKGFYK KKQCRPSKGR KRGFCWCVDK YGQPLPGYTT KGKEDVHCYS MQSK
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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