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You are here:Home » Molecular Biology » Growth Factors-IGF » IGF2BP2, Recombinant, Human (Insulin-like Growth Factor 2 mRNA-binding Protein 2, IGF2 mRNA-binding Protein 2, IMP-2, Hepatocellular Carcinoma Autoantigen p62, IGF-II mRNA-binding Protein 2, VICKZ Family Member 2, IMP2, VICKZ2)

IGF2BP2, Recombinant, Human (Insulin-like Growth Factor 2 mRNA-binding Protein 2, IGF2
mRNA-binding Protein 2, IMP-2, Hepatocellular Carcinoma Autoantigen p62, IGF-II
mRNA-binding Protein 2, VICKZ Family Member 2, IMP2, VICKZ2)

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Specifications

The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67aa, respectively, and 3 intra-molecular disulfide bonds.
Catalog #149579
SourceRecombinant protein corresponding to human IGF-II, expressed in E. coli.
Biological ActivityDetermined by a cell proliferation assay using FDC-P1 cells. The ED50 was found to be 2ng/ml.
Specific Activity5x10e5units/mg.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceAYRPSETLCG GELVDTLQFV CGDRGFYFSR PASRVSRRSR GIVEECCFRS CDLALLETYC ATPAKSE
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceE. coli
Purity~98% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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