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You are here:Home » Growth Factors, Cytokines » Growth Factors-VEGF » VEGFC, Recombinant, Human (Vascular Endothelial Growth Factor C, VEGF-C, Flt4 ligand, Flt4-L, Vascular Endothelial Growth Factor-related Protein, VRP)

VEGFC, Recombinant, Human (Vascular Endothelial Growth Factor C, VEGF-C, Flt4 ligand,
Flt4-L, Vascular Endothelial Growth Factor-related Protein, VRP)

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Specifications

VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-C is a 13.5kD non-disulfide linked homodimeric protein consisting of two 116aa polypeptide chains.
Catalog #149583
SourceRecombinant protein corresponding to human VEGF-C, expressed in HEK 293.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceMAHYNTEILK SIDNEWRKTQ CMPREVCIDV GKEFGVATNT FFKPPCVSVY RCGGCCNSEG LQCMNTSTSY LSKTLFEITV PLSQGPKPVT ISFANHTSCR CMSKLDVYRQ VHSIIRR
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
SourceHEK293
Purity~95% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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