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You are here:Home » Molecular Biology » Growth Factors-VEGF » VEGFD, Recombinant, Human (Vascular Endothelial Growth Factor D, VEGF-D, c-Fos-induced Growth Factor, FIGF, FIGF)

VEGFD, Recombinant, Human (Vascular Endothelial Growth Factor D, VEGF-D, c-Fos-induced
Growth Factor, FIGF, FIGF)

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Specifications

VEGF-D, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-D is highly expressed in the lung, heart, small intestine and fetal lung, and at lower levels in the skeletal muscle, colon, and pancreas. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-D may play a role in the formation of the venous and lymphatic vascular systems. It also participates in the growth and maintenance of differentiated lymphatic endothelium in adults. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-D is a 13.1kD non-disulfide linked homodimeric protein consisting of two 117aa polypeptide chains. Due to glycosylation the protein migrates as a 20-22kD band under non-reducing condition.
Catalog #149584
SourceRecombinant protein corresponding to human VEGF-D, expressed in 293 cells.
Endotoxin<0.1ng/ug (1EU/ug)
AA SequenceFAATFYDIET LKVIDEEWQR TQCSPRETCV EVASELGKST NTFFKPPCVN VFRCGGCCNE ESLICMNTST SYISKQLFEI SVPLTSVPEL VPVKVANHTG CKCLPTAPRH PYSIIRR
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source293 cells
Purity~95% (SDS-PAGE and HPLC)
ConcentrationAs reported
FormSupplied as a lyophilized powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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